035 Dysfunction of CD19 + CD24 hi CD27 + B regulatory cells in patients with bullous pemphigoid

Regulatory T cells in skin lesions and blood of patients with bullous pemphigoid.

BACKGROUND Although regulatory T cells (Tregs) are affected in several autoimmune skin diseases, only two studies have been performed in patients with bullous pemphigoid (BP) with contrasting results. OBJECTIVE To characterize Tregs and to determine the serum levels of regulatory cytokines in patients with BP. METHODS In BP lesional skin, immunohistochemistry and confocal microscopy were pe...

Altered B cell balance, but unaffected B cell capacity to limit monocyte activation in anti-neutrophil cytoplasmic antibody-associated vasculitis in remission.

OBJECTIVE Regulatory B cells (Bregs) constitute a subset of B cells with immunomodulatory properties. Numerical and functional alterations in the Breg compartment have been associated with autoimmunity. The aim of this study was to assess the frequency and function of Bregs in patients with ANCA-associated vasculitis (AAV). METHODS B cell subsets were determined in the peripheral blood of 48 ...

Decrease in Proportion of CD19+CD24hiCD27+ B Cells and Impairment of Their Suppressive Function in Graves’ Disease

IL-10-producing B cells (B10 cells) have been shown to play a suppressive role in the peripheral blood of humans, with their numbers and function altered in several autoimmune diseases. However, the role of B10 cells in Graves' disease (GD) remains unknown. In this study, we demonstrated that B10 cells in human peripheral blood belonged to a CD24(hi)CD27(+) B cell subpopulation. The proportion ...

Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross-sectional study

INTRODUCTION IL-10-producing B cells, Foxp3-expressing T cells (Tregs) and the IDO-expressing dendritic cells (pDC) are able to modulate inflammatory processes, to induce immunological tolerance and, in turn, to inhibit the pathogenesis of autoimmune disease. The aim of the study was to characterize and to enumerate peripheral IL-10--producing B cells, Tregs and pDCregs in primary Sjögren's Syn...

Bullous pemphigoid